Levaquin

[Levofloxacin]

These recommendations apply to patients with normal renal function (i. e., creatinine clearance > 80 mL/ min). For patients with altered renal function see the Patients with Impaired Renal Function subsection. Oral doses should be administered at least two hours before or two hours after antacids containing magnesium, aluminum, as well as sucralfate, metal cations such as iron, and multi-vitamin preparations with zinc or Videx ® (didanosine), chewable/ buffered tablets or the pediatric powder for oral solution.

Patients with Normal Renal Function Infection* Unit Dose Freq. Duration** Daily Dose

Comm. Acquired Pneumonia 500 mg q24h 7-14 days 500 mg Comm. Acquired Pneumonia 750 mg*** q24h 5 days 750 mg
Nosocomial Pneumonia 750 mg q24h 7-14 days 750 mg Complicated SSSI 750 mg q24h 7-14 days 750 mg
Acute Bacterial Exacerbation of Chronic Bronchitis 500 mg q24h 7 days 500 mg
Acute Maxillary Sinusitis 500 mg q24h 10-14 days 500 mg Uncomplicated SSSI 500 mg q24h 7-10 days 500 mg
Chronic Bacterial Prostatitis 500 mg q24h 28 days 500 mg Complicated UTI 250 mg q24h 10 days 250 mg
Acute pyelonephritis 250 mg q24h 10 days 250 mg Uncomplicated UTI 250 mg q24h 3 days 250 mg

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* DUE TO THE DESIGNATED PATHOGENS (See INDICATIONS AND USAGE.)
** Sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.
*** Efficacy of this alternative regimen has only been documented for infections caused by penicillin-susceptible Streptococcus pneumoniae,
Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae and Chlamydia pneumoniae.

Patients with Impaired Renal Function Renal Status Initial Dose Subsequent Dose
Acute Bacterial Exacerbation of Chronic Bronchitis / Comm. Acquired Pneumonia / Acute Maxillary Sinusitis /
Uncomplicated SSSI/ Chronic Bacterial Prostatitis CLCR from 50 to 80 mL/ min No dosage adjustment required
CLCR from 20 to 49 mL/ min 500 mg 250 mg q24h CLCR from 10 to 19 mL/ min 500 mg 250 mg q48h
Hemodialysis 500 mg 250 mg q48h CAPD 500 mg 250 mg q48h

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