Levaquin

[Levofloxacin]

Complicated SSSI/ Nosocomial Pneumonia/ Comm. Acquired Pneumonia
CLCR from 50 to 80 mL/ min No dosage adjustment required CLCR from 20 to 49 mL/ min 750 mg 750 mg q48h
CLCR from 10 to 19 mL/ min 750 mg 500 mg q48h Hemodialysis 750 mg 500 mg q48h
CAPD 750 mg 500 mg q48h
Complicated UTI / Acute Pyelonephritis CLCR 20 mL/ min No dosage adjustment required

CLCR from 10 to 19 mL/ min 250 mg 250 mg q48h
Uncomplicated UTI No dosage adjustment required CLCR =creatinine clearances

CAPD= chronic ambulatory peritoneal dialysis
When only the serum creatinine is known, the following formula may be
used to estimate creatinine clearance.

Text Continues Below

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Men: Creatinine Clearance (mL/ min) =
Weight (kg) x (140 Ð age)
72 x serum creatinine (mg/ dL)
Women: 0.85 x the value calculated for men.

The serum creatinine should represent a steady state of renal function.
Preparation of Levofloxacin Injection for Administration LEVAQUIN Injection in Single-Use Vials: LEVAQUIN Injection is sup-plied in single-use vials containing a concentrated levofloxacin solution with the equivalent of 500 mg (20 mL vial) and 750 mg (30 mL vial) of levofloxacin in Water for Injection, USP. The 20 mL and 30 mL vials each contain 25 mg of levofloxacin/ mL.

THESE LEVAQUIN INJECTION SINGLE-USE VIALS MUST BE FURTHER DILUTED WITH AN APPROPRIATE SOLUTION PRIOR TO INTRAVENOUS ADMINISTRATION. (See COMPATIBLE INTRAVENOUS SOLUTIONS.) The concentration of the resulting diluted solution should be 5 mg/ mL prior to administration.

This intravenous drug product should be inspected visually for particu-late matter prior to administration. Samples containing visible particles should be discarded. Since no preservative or bacteriostatic agent is present in this product, aseptic technique must be used in preparation of the final intravenous solution. Since the vials are for single-use only, any unused portion remaining in the vial should be discarded. When used to prepare two 250 mg doses from the 20 mL vial containing 500 mg of levofloxacin, the full content of the vial should be withdrawn at once using a single-entry procedure, and a second dose should be prepared and stored for subsequent use. (See Stability of LEVAQUIN Injection Following Dilution.)

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