|
2. For prevention of postmenopausal osteoporosis: When prescribing solely for the prevention of postmenopausal osteoporosis, therapy should be considered only for women at significant risk of osteoporosis and non-estrogen medications should be carefully considered. Patients should be treated with the lowest effective dose. Generally women should be started at 0.3 mg Premarin daily. Subsequent dosage adjustment may be made based upon the individual clinical and bone mineral density responses. This dose should be periodically reassessed by the healthcare provider. Premarin therapy may be given continuously with no interruption in therapy, or in cyclical regimens (regimens such as 25 days on drug followed by five days off drug) as is medically appropriate on an individualized basis. Text Continues Below
3. For treatment of female hypoestrogenism due to hypogonadism, castration, or primary ovarian failure: Female hypogonadism 0.3 mg or 0.625 mg daily, administered cyclically (e. g., three weeks on and one week off). Doses are adjusted depending on the severity of symptoms and responsiveness of the endometrium. In clinical studies of delayed puberty due to female hypogonadism, breast development was induced by doses as low as 0.15 mg. The dosage may be gradually titrated upward at 6 to 12 month intervals as needed to achieve appropriate bone age advancement and eventual epiphyseal closure. Clinical studies suggest that doses of 0.15 mg, 0.3 mg, and 0.6 mg are associated with mean ratios of bone age advancement to chronological age progression ( BA/ CA) of 1.1, 1.5, and 2.1, respectively. (Premarin in the dose strength of 0.15 mg is not available commercially). Available data suggest that chronic dosing with 0.625 mg is sufficient to induce artificial cyclic menses with sequential progestin treatment and to maintain bone mineral density after skeletal maturity is achieved. Page: << Prev | 1 | 2 | 3 | 4 | Next >>
|
.gif)
