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Overdosage & Contraindications
CONTRAINDICATIONS
Estrogens/ progestins combined should not be used in women with any of the following conditions: 1. Undiagnosed abnormal genital bleeding. Text Continues Below
2. Known, suspected, or history of cancer of the breast. 3. Known or suspected estrogen-dependent neoplasia. 4. Active deep vein thrombosis, pulmonary embolism or a history of these conditions. 5. Active or recent (e. g., within past year) arterial thromboembolic disease (e. g., stroke, myocardial infarction). 6. Liver dysfunction or disease. 7. PREMPRO or PREMPHASE therapy should not be used in patients with known hypersensitivity to their ingredients. 8. Known or suspected pregnancy. There is no indication for PREMPRO or PREMPHASE in pregnancy. There appears to be little or no increased risk of birth defects in women who have used estrogen and progestins from oral contraceptives inadvertently during pregnancy. (See PRECAUTIONS.) OVERDOSAGE Serious ill effects have not been reported following acute ingestion of large doses of estrogen/ progestin-containing oral contraceptives by young children. Overdosage of estrogen/ progestin may cause nausea and vomiting, and withdrawal bleeding may occur in females.
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