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Topamax

[Topiramate]

Events are classified within body system categories and enumerated in order of decreasing frequency using the following definitions: frequent occurring in at least 1/ 100 patients; infrequent occurring in 1/ 100 to 1/ 1000 patients; rare occurring in fewer than 1/ 1000 patients.

Autonomic Nervous System Disorders

Infrequent: vasodilation.

Text Continues Below



Body as a Whole

Infrequent: syncope, abdomen enlarged. Rare: alcohol intolerance.

Cardiovascular Disorders, General

Infrequent: hypotension, postural hypotension.

Central & Peripheral Nervous System Disorders

Frequent: hypertonia. Infrequent: neuropathy, apraxia, hyperaesthesia, dyskinesia, dys-phonia, scotoma, ptosis, dystonia, visual field defect, encephalopathy, EEG abnormal. Rare: upper motor neuron lesion, cerebellar syndrome, tongue paralysis.

Gastrointestinal System Disorders

Frequent: diarrhea, vomiting. Infrequent: hemorrhoids, stomatitis, melena, gastritis, tongue edema, esophagitis.

Heart Rate and Rhythm Disorders: Infrequent: AV block.

Liver and Biliary System Disorders

Infrequent: SGPT increased, SGOT increased, gamma-GT increased.

Metabolic and Nutritional Disorders

Frequent: dehydration. Infrequent: hypokalemia, alkaline phosphatase increased, hypocalcemia, hyperlipemia, acidosis, hyperglycemia, xerophthalmia. Rare: hyperchloremia, diabetes mellitus, hypernatremia, hyponatremia, hypocholesterolemia, hypophosphatemia, creatinine increased.

Musculoskeletal System Disorders

Frequent: arthralgia. Infrequent: arthrosis.

Myo-, Endo-, Pericardial & Valve Disorders

Infrequent: angina pectoris.

Neoplasms: Infrequent: thrombocythemia. Rare: polycythemia.

Platelet, Bleeding, and Clotting Disorders: Infrequent: gingival bleeding. Rare: pulmonary embolism.

Psychiatric Disorders

Frequent: impotence, hallucination, euphoria, psychosis, suicide attempt. Infrequent: paranoid reaction, delusion, paranoia, delirium, abnormal dreaming, neurosis. Rare: libido increased, manic reaction.

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