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The responses of serum glucose, insulin, C-peptide, and plasma glucagon to 2 mg AMARYL were unaffected by coadministration of ramipril (an ACE inhibitor) 5 mg once daily in normal subjects. No hypoglycemic symptoms were reported. Pooled data from clinical trials in patients with NIDDM showed no evidence of clinically significant adverse interactions with uncontrolled concurrent administration of ACE inhibitors. A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. Text Continues Below
Potential interactions of glimepiride with other drugs metabolized by cytochrome P450 II C9 also include phenytoin, diclofenac, ibuprofen, naproxen, and mefenamic acid. Although no specific interaction studies were performed, pooled data from clinical trials showed no evidence of clinically significant adverse interactions with uncontrolled concurrent administration of calcium-channel blockers, estrogens, fibrates, NSAIDS, HMG CoA reductase inhibitors, sulfonamides, or thyroid hormone.
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