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Indications & Dosage
INDICATIONS AND USAGE
Hypertension TOPROL-XL is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Angina Pectoris TOPROL-XL is indicated in the long-term treatment of angina pectoris. Heart Failure Text Continues Below
TOPROL-XL is indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digi-talis.
In this population, TOPROL-XL decreased the rate of mortality plus hospitalization, largely through a reduction in cardiovascular mortality and hospitaliza-tions for heart failure. DOSAGE AND ADMINISTRATION TOPROL-XL is an extended release tablet intended for once-a-day administration. When switching from immediate release metoprolol tablet to TOPROL-XL, the same total daily dose of TOPROL-XL should be used. As with immediate release metoprolol, dosages of TOPROL-XL should be individualized and titration may be needed in some patients. TOPROL-XL tablets are scored and can be divided; however, the whole or half tablet should be swallowed whole and not chewed or crushed. Hypertension The usual initial dosage is 50 to 100 mg daily in a single dose, whether used alone or added to a diuretic. The dosage may be increased at weekly (or longer) intervals until optimum blood pressure reduction is achieved. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy. Dosages above 400 mg per day have not been studied. Angina Pectoris The dosage of TOPROL-XL should be individualized. The usual initial dosage is 100 mg daily, given in a single dose. The dosage may be gradually increased at weekly intervals until optimum clinical response has been obtained or there is a pronounced slowing of the heart rate. Dosages above 400 mg per day have not been studied. If treatment is to be discontinued, the dosage should be reduced gradually over a period of 1Ð 2 weeks
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