Prinivil

[lisinopril]

Agents Increasing Serum Potassium

Since lisinopril decreases aldosterone production, elevation of serum potassium may occur. Potassium sparing diuretics such as spironolactone, triamterene or amiloride, or potassium supplements should be given only for documented hypokalemia and with caution and with frequent monitoring of serum potassium since they may lead to a significant increase in serum potassium. Potassium-containing salt substitutes should also be used with caution.

Agents Causing Renin Release

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The antihypertensive effect of PRINIVIL ® is augmented by antihypertensive agents that cause renin release (e. g., diuretics).

Agents Affecting Sympathetic Activity

Agents affecting sympathetic activity (e. g., ganglionic blocking agents or adrenergic neuron blocking agents) may be used with caution. Beta-adrenergic blocking drugs add some further antihypertensive effect to lisinopril.

NSAIDs

The antihypertensive effect of lisinopril may be diminished with concomitant non-steroidal anti-inflammatory drug use. In some patients with compromised renal function who are being treated with non-steroidal anti-inflammatory drugs, the co-administration of ACE inhibitors may result in further deterioration of renal function.

Indomethacin may diminish the antihypertensive efficacy of concomitantly administered PRINIVIL ® .

Lithium Salts

As with other drugs which eliminate sodium, the lithium elimination may be reduced. Therefore, the serum lithium levels should be monitored carefully if lithium salts are to be administered.

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