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Following multiple doses of lisinopril, the effective half-life of accumulation is 12 hours. In a study in elderly healthy subjects (65 years and above), a single dose of lisinopril 20 mg produced higher serum concentrations than those seen in young healthy adults given a similar dose. In another study, single daily doses of lisinopril 5 mg were given for 7 consecutive days to young and elderly healthy volunteers and to elderly patients with congestive heart failure. Maximum serum concentrations of lisinopril on Day 7 were higher in the elderly volunteers than in the young, and still higher in the elderly patients with congestive heart failure. Renal clearance of lisinopril was decreased in the elderly, particularly in the presence of congestive heart failure. The elimination of lisinopril in patients with renal insufficiency is similar to that in patients with normal renal function until the glomerular filtration rate is 30 mL/ min or less. With renal function 30 mL/ min, peak and trough lisinopril levels increase, time to peak concentration increases and time to steady state is prolonged (see DOSAGE AND ADMINISTRATION). Studies in rats indicate that lisinopril crosses the blood-brain barrier poorly. Text Continues Below
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