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Warnings & Precautions
PRECAUTIONS
General Symptomatic response to therapy with pantoprazole does not preclude the presence of gastric malignancy. Owing to the chronic nature of erosive esophagitis, there may be a potential for prolonged administration of pantoprazole. In long-term rodent studies, pantoprazole was carcinogenic and caused rare types of gastrointestinal tumors. The relevance of these findings to tumor development in humans is unknown. Text Continues Below
Generally, daily treatment with any acid-suppressing medications over a long period of time (e. g. longer than 3 years) may lead to malabsorption of cyanocobalamin (Vitamin B-12) caused by hypo-or achlorhydria. Rare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literature. This possibility should be considered if clinical symptoms consistent with cyanocobalamin deficiency are observed.
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