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Lansoprazole inhibited the normal increases in secretion volume, acidity and acid output induced by insulin. In a crossover study that included lansoprazole 15 and 30 mg for five days, the following effects on intragastric pH were noted: Mean Antisecretory Effects After Single and Multiple Daily Dosing PREVACID Baseline 15 mg 30 mg
Parameter Value Day 1 Day 5 Day 1 Day 5 Text Continues Below
Mean 24-Hour pH 2. 1 2. 7 + 4. 0 + 3. 6 * 4. 9 *
Mean Nighttime pH 1. 9 2. 4 3. 0 + 2. 6 3. 8 *
% Time Gastric pH> 3 18 33 + 59 + 51 * 72 *
% Time Gastric pH> 4 12 22 + 49 + 41 * 66 *
NOTE: An intragastric pH of >4 reflects a reduction in gastric acid by 99%. * (p< 0. 05) versus baseline and lansoprazole 15 mg.
+ (p< 0. 05) versus baseline only. After the initial dose in this study, increased gastric pH was seen within 1-2 hours with lansoprazole 30 mg and 2-3 hours with lansoprazole 15 mg. After multiple daily dosing, increased gastric pH was seen within the first hour postdosing with lansoprazole 30 mg and within 1-2 hours postdosing with lansoprazole 15 mg. PREVACID Acid suppression may enhance the effect of antimicrobials in eradicating Helicobacter pylori (H. pylori). The percentage of time gastric pH was elevated above 5 and 6 was evaluated in a crossover study of PREVACID given q. d., b. i. d. and t. i. d. Mean Antisecretory Effects After 5 Days of b. i. d. and t. i. d. Dosing PREVACID Parameter 30 mg q. d. 15 mg b. i. d. 30 mg b. i. d. 30 mg t. i. d.
% Time Gastric pH> 5 43 47 59 + 77 *
% Time Gastric pH> 6 20 23 28 45 * +
(p< 0. 05) versus PREVACID 30 mg q. d. * (p< 0. 05) versus PREVACID 30 mg q. d., 15 mg b. i. d. and 30 mg b. i. d. The inhibition of gastric acid secretion as measured by intragastric pH returns gradually to normal over two to four days after multiple doses. There is no indication of rebound gastric acidity. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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