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Drug DescriptionSide Effects & Drug InteractionsWarnings & Precautions
Clinical PharmacologyOverdosage & ContraindicationsIndications & Dosage

Advair Diskus

[Salmeterol/Fluticasone]

Improvement in asthma control following inhaled administration of ADVAIR DISKUS can occur within 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment. Individual patients will experience a variable time to onset and degree of symptom relief.

For patients who do not respond adequately to the starting dosage after 2 weeks of therapy, replacing the current strength of ADVAIR DISKUS with
If a previously effective dosage regimen of ADVAIR DISKUS fails to provide adequate improvement in asthma control, the therapeutic regimen should be reevaluated and additional therapeutic options, e.g., replacing the current strength of ADVAIR DISKUS with a higher strength, adding additional inhaled corticosteroid, or initiating oral corticosteroids, should be considered.

Chronic Obstructive Pulmonary Disease Associated With Chronic Bronchitis:

The dosage for adults is 1 inhalation (250/50 mcg) twice daily (morning and evening, approximately 12 hours apart). ADVAIR DISKUS 250/50 mcg twice daily is the only approved dosage for the treatment of COPD associated with chronic bronchitis. Higher doses, including ADVAIR DISKUS 500/50, are not recommended, as no additional improvement in lung function was observed in clinical trials and higher doses of corticosteroids increase the risk of systemic effects.

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If shortness of breath occurs in the period between doses, an inhaled, short-acting beta2-agonist should be taken for immediate relief. Patients who are receiving ADVAIR DISKUS twice daily should not use additional salmeterol or other inhaled, long-acting beta2-agonists (e.g., formoterol) for the maintenance treatment of COPD or for any other reason.

Geriatric Use

In studies where geriatric patients (65 years of age or older, see PRECAUTIONS: Geriatric Use) have been treated with ADVAIR DISKUS, efficacy and safety did not differ from that in younger patients. Based on available data for ADVAIR DISKUS and its active components, no dosage adjustment is recommended.

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