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Bipolar Disorder Usual Monotherapy Dose - Olanzapine should be administered on a once-a-day schedule without regard to meals, generally beginning with 10 or 15 mg. Dosage adjustments, if indicated, should generally occur at intervals of not less than 24 hours, reflecting the procedures in the placebo-controlled trials. When dosage adjustments are necessary, dose increments/ decrements of 5 mg QD are recommended. Short-term (3-4 weeks) antimanic efficacy was demonstrated in a dose range of 5 mg to 20 mg/ day in clinical trials. The safety of doses above 20 mg/ day has not been evaluated in clinical trials. Maintenance Monotherapy - The benefit of maintaining bipolar patients on monotherapy with ZYPREXA at a dose of 5 to 20 mg/ day, after achieving a responder status for an average duration of two weeks, was demonstrated in a controlled trial (see Clinical Efficacy Data under CLINICAL PHARMACOLOGY). The physician who elects to use ZYPREXA for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. Bipolar Mania Usual Dose in Combination with Lithium or Valproate - When administered in combination with lithium or valproate, olanzapine dosing should generally begin with 10 mg once-a-day without regard to meals. Short-term (6 weeks) antimanic efficacy was demonstrated in a dose range of 5 mg to 20 mg/ day in clinical trials. The safety of doses above 20 mg/ day has not been evaluated in clinical trials. Dosing in Special Populations - See Dosing in Special Populations under DOSAGE AND ADMINISTRATION, Schizophrenia. Administration of ZYPREXA ZYDIS (olanzapine orally disintegrating tablets) Text Continues Below
After opening sachet, peel back foil on blister. Do not push tablet through foil. Immediately upon opening the blister, using dry hands, remove tablet and place entire ZYPREXA ZYDIS in the mouth. Tablet disintegration occurs rapidly in saliva so it can be easily swallowed with or without liquid. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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