|
A study of outpatients with major depressive disorder who had responded to PAXIL (HDRS total score <8) during an initial 8-week open-treatment phase and were then randomized to continuation on PAXIL or placebo for 1 year demonstrated a significantly lower relapse rate for patients taking PAXIL (15%) compared to those on placebo (39%). Effectiveness was similar for male and female patients.
Obsessive Compulsive Disorder: The effectiveness of PAXIL in the treatment of obsessive compulsive disorder (OCD) was demonstrated in two 12-week multicenter placebo-controlled studies of adult outpatients (Studies 1 and 2). Patients in all studies had moderate to severe OCD (DSM-IIIR) with mean baseline ratings on the Yale Brown Obsessive Compulsive Scale (YBOCS) total score ranging from 23 to 26. Study 1, a dose-range finding study where patients were treated with fixed doses of 20, 40, or 60 mg of paroxetine/ day demonstrated that daily doses of paroxetine 40 and 60 mg are effective in the treatment of OCD. Text Continues Below
Patients receiving doses of 40 and 60 mg paroxetine experienced a mean reduction of approximately 6 and 7 points, respectively, on the YBOCS total score which was significantly greater than the approximate 4-point reduction at 20 mg and a 3-point reduction in the placebo-treated patients. Study 2 was a flexible-dose study comparing paroxetine (20 to 60 mg daily) with clomipramine (25 to 250 mg daily). In this study, patients receiving paroxetine experienced a mean reduction of approximately 7 points on the YBOCS total score, which was significantly greater than the mean reduction of approximately 4 points in placebo-treated patients. The following table provides the outcome classification by treatment group on Global Improvement items of the Clinical Global Impression (CGI) scale for Study 1. Outcome Classification (%) on CGI-Global Improvement Item for Completers in Study 1 Outcome Classification Placebo (n = 74) PAXIL 20 mg (n = 75) PAXIL 40 mg (n = 66) PAXIL 60 mg (n = 66) Worse 14% 7% 7% 3%
No Change 44% 35% 22% 19% Minimally Improved 24% 33% 29% 34%
Much Improved 11% 18% 22% 24% Very Much Improved 7% 7% 20% 20% Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
|
.gif)
