|
Pediatric Patients Age 3– 12 years: The starting dose should range from 10-15 mg/ kg/ day in 3 divided doses, and the effective dose reached by upward titration over a period of approximately 3 days. The effective dose of Neurontin ® in patients 5 years of age and older is 25– 35 mg/ kg/ day and given in divided doses (three times a day). The effective dose in pediatric patients ages 3 and 4 years is 40 mg/ kg/ day and given in divided doses (three times a day) (see CLINICAL PHARMACOLOGY, Pediatrics.) Neurontin may be administered as the oral solution, capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/ kg/ day have been well-tolerated in a long-term clinical study. The maximum time interval between doses should not exceed 12 hours. It is not necessary to monitor gabapentin plasma concentrations to optimize Neurontin ® therapy. Further, because there are no significant pharmacokinetic interactions among Neurontin ® and other commonly used antiepileptic drugs, the addition of Neurontin ® does not alter the plasma levels of these drugs appreciably. Text Continues Below
If Neurontin ® is discontinued and/ or an alternate anticonvulsant medication is added to the therapy, this should be done gradually over a minimum of 1 week. Dosage in Renal Impairment Creatinine clearance is difficult to measure in outpatients. In patients with stable renal function, creatinine clearance (CCr) can be reasonably well estimated using the equation of Cockcroft and Gault: for females CCr=( 0.85)( 140-age)( weight)/[( 72)( SCr)] for males CCr=( 140-age)( weight)/[( 72)( SCr)] where age is in years, weight is in kilograms and SCr is serum creatinine in mg/ dL. Dosage adjustment in patients 12 years of age with compromised renal function or undergoing hemodialysis is recommended as follows (see dosing recommendations above for effective doses in each indication). Page: << Prev | 1 | 2 | 3 | 4 | Next >>
|
.gif)
