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Drug Description
DESCRIPTION
ZESTORETIC ® (Lisinopril and Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. It is chemically described as (S)-1-[ N 2 -( 1-carboxy-3-phenylpropyl)-L-lysyl] -L-proline dihydrate. Its empirical formula is C 21 H 31 N 3 O 5 . 2H 2 O Text Continues Below
Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water, sparingly soluble in methanol, and practically insoluble in ethanol. ZESTORETIC ® (Lisinopril and Hydrochlorothiazide)
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C 7 H 8 ClN 3 O 4 S 2 Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.72, which is slightly soluble in water, but freely soluble in sodium hydroxide solution. ZESTORETIC is available for oral use in three tablet combinations of lisinopril with hydrochlorothiazide: ZESTORETIC 10-12.5 containing 10 mg lisinopril and 12.5 mg hydrochlorothiazide; ZESTORETIC 20-12.5 containing 20 mg lisinopril and 12.5 mg hydrochlorothiazide; and, ZESTORETIC 20-25 containing 20 mg lisinopril and 25 mg hydrochlorothiazide. Inactive Ingredients:
10-12.5 Tablets -calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch, yellow ferric oxide. 20-12.5 Tablets -calcium phosphate, magnesium stearate, mannitol, starch.
20-25 Tablets -calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch, yellow ferric oxide.
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