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Clarithromycin Tissue Concentrations 2 hours after Dose 1
Tissue Clarithromycin Clarithromycin + Omeprazole
Antrum
Fundus
Mucus 10.48 ± 2.01 (n = 5)
20.81 ± 7.64 (n = 5)
4.15 ± 7.74 (n = 4) 19.96 ± 4.71 (n = 5)
24.25 ± 6.37 (n = 5)
39.29 ± 32.79 (n = 4) 1
Mean ± SD (mg/ g) Text Continues Below
For information on clarithromycin pharmacokinetics and microbiology, consult the clarithromycin package insert, CLINICAL PHARMACOLOGY section. The pharmacokinetics of omeprazole, clarithromycin, and amoxicillin have not been adequately studied when all three drugs are administered concomitantly. For information on amoxicillin pharmacokinetics and microbiology, see the amoxicillin package insert, ACTIONS, PHARMACOLOGY and MICROBIOLOGY sections. Pharmacodynamics Mechanism of Action Omeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2
histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H + /K + ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. Animal studies indicate that after rapid disappearance from plasma, omeprazole can be found within the gastric mucosa for a day or more. Antisecretory Activity After oral administration, the onset of the antisecretory effect of omeprazole occurs within one hour, with the maximum effect occurring within two hours. Inhibition of secretion is about 50% of maximum at 24 hours and the duration of inhibition lasts up to 72 hours. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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