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Prempro

[Conjugated Estrogens/Medroxyprogesterone]

treat moderate to severe dryness, itching, and burning, in and around the vagina. You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO or PREMPHASE to control these problems.

help reduce your chances of getting osteoporosis (thin weak bones). Osteoporosis from menopause is a thinning of the bones that makes them weaker and easier to break. If you use PREMPRO or PREMPHASE only to prevent osteoporosis from menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.

You and your healthcare provider should talk regularly about whether you should continue with PREMPRO or PREMPHASE.

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Weight-bearing exercise, like walking or running, and taking calcium and vitamin D supplements may also lower your chances of getting postmenopausal osteoporosis. It is important to talk about exercise and supplements with your healthcare provider before starting them.

Who should not take PREMPRO or PREMPHASE?

Do not take PREMPRO or PREMPHASE if you have had your uterus removed (hysterectomy).

PREMPRO and PREMPHASE contain a progestin to decrease the chances of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not take PREMPRO or PREMPHASE.

Do not start taking PREMPRO or PREMPHASE if you:

have unusual vaginal bleeding.
currently have or have had certain cancers. Estrogens may increase the chances of getting certain types of cancers, including cancer of the breast or uterus. If you have or had cancer, talk with your healthcare provider about whether you should take PREMPRO or PREMPHASE.

had a stroke or heart attack in the past year.
currently have or have had blood clots.
have liver problems.
are allergic to PREMPRO or PREMPHASE or any of their ingredients. See the end of this leaflet for a list of all the ingredients in PREMPRO and PREMPHASE.

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