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Suppressive Therapy The recommended dosage of VALTREX for chronic suppressive therapy of recurrent genital herpes is 1 gram once daily in patients with normal immune function. In patients with a history of 9 or fewer recurrences per year, an alternative dose is 500 mg once daily. The safety and efficacy of therapy with VALTREX beyond 1 year have not been established. In HIV-infected patients with CD4 cell count 100 cells/mm 3 , the recommended dosage of VALTREX for chronic suppressive therapy of recurrent genital herpes is 500 mg twice daily. The safety and efficacy of therapy with VALTREX beyond 6 months in patients with HIV infection have not been established. Text Continues Below
Reduction of Transmission The recommended dosage of VALTREX for reduction of transmission of genital herpes in patients with a history of 9 or fewer recurrences per year is 500 mg once daily for the source partner. Patients should be counseled to use safer sex practices in combination with suppressive therapy with VALTREX. The efficacy of reducing transmission beyond 8 months in discordant couples has not been established. Cold Sores (Herpes Labialis) The recommended dosage of VALTREX for the treatment of cold sores is 2 grams twice daily for 1 day taken about 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning). There are no data on the effectiveness of treatment initiated after the development of clinical signs of a cold sore (e.g., papule, vesicle, or ulcer). Patients with Acute or Chronic Renal Impairment In patients with reduced renal function, reduction in dosage is recommended (see Table 7). Table 7. Dosages for Patients with Renal Impairment
Creatinine Clearance (mL/min) Indications
Normal Dosage
Regimen
(Creatinine
Clearance 50) 30-49 10-29 <10 Page: << Prev | 1 | 2 | 3 | Next >>
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