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Table 2. Incidence of Weight Gain and Weight Loss in Placebo-Controlled Trials
Weight Change
WELLBUTRIN SR 300 mg/ day
(n = 339)
WELLBUTRIN SR 400 mg/ day
(n = 112) Placebo (n = 347) Gained >5 lbs 3% 2% 4%
Lost >5 lbs 14% 19% 6%
In studies conducted with the immediate-release formulation of bupropion, 35% of patients receiving tricyclic antidepressants gained weight, compared to 9% of patients treated with the immediate-release formulation of bupropion. If weight loss is a major presenting sign of a patient's depressive illness, the anorectic and/ or weight-reducing potential of WELLBUTRIN SR Tablets should be considered. Suicide: The possibility of a suicide attempt is inherent in depression and may persist until significant remission occurs. Accordingly, prescriptions for WELLBUTRIN SR Tablets should be written for the smallest number of tablets consistent with good patient management. Allergic Reactions Anaphylactoid/ anaphylactic reactions characterized by symptoms such as pruritus, urticaria, angioedema, and dyspnea requiring medical treatment have been reported in clinical trials with bupropion. In addition, there have been rare spontaneous postmarketing reports of erythema multiforme, Stevens-Johnson syndrome, and anaphylactic shock associated with bupropion. A patient should stop taking WELLBUTRIN SR and consult a doctor if experiencing allergic or anaphylactoid/ anaphylactic reactions (e. g., skin rash, pruritus, hives, chest pain, edema, and shortness of breath) during treatment. Arthralgia, myalgia, and fever with rash and other symptoms suggestive of delayed hypersensitivity have been reported in association with bupropion. These symptoms may resemble serum sickness. Text Continues Below
Cardiovascular Effects In clinical practice, hypertension, in some cases severe, requiring acute treatment, has been reported in patients receiving bupropion alone and in combination with nicotine replacement therapy. These events have been observed in both patients with and without evidence of preexisting hypertension. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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