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Drug DescriptionSide Effects & Drug InteractionsWarnings & Precautions
Clinical PharmacologyOverdosage & ContraindicationsIndications & DosagePatient Info

Combivent

[ipratropium bromide and albuterol sulfate]


Side Effects & Drug Interactions
ADVERSE REACTIONS


Additional adverse reactions, reported in less than two percent of the patients in the Combivent Inhalation Aerosol treatment group include

Text Continues Below



edema,
fatigue,
hypertension,
dizziness,
nervousness,
paresthesia,
tremor,
dysphonia,
insomnia,
diarrhea,
dry mouth,
dyspepsia,
vomiting,
arrhythmia,
palpitation,
tachycardia,
arthralgia,
angina,
increased sputum,
taste perversion,
urinary tract infection/ dysuria.

Allergic-type reactions such as

skin rash,
angioedema of tongue, lips and face,
urticaria (including giant urticaria),
laryngospasm,
anaphylactic reaction

have been reported, with positive rechallenge in some cases. Many of these patients had a history of allergies to other drugs and/ or foods including soybean (See CONTRAINDICATIONS).

Additional information derived from the published literature and post-marketing surveillance on the use of ipratropium or albuterol inhalation aerosol singly or in combination that is not included in the lists above includes:

cases of precipitation or worsening of narrow-angle glaucoma,
acute eye pain,
blurred vision,
nasal congestion,
drying of secretions,
mucosal ulcers,
irritation from aerosol,
paradoxical bronchospasm,
wheezing,
exacerbation of COPD symptoms,
heartburn,
drowsiness,
CNS stimulation,
coordination difficulty,
weakness,
itching,
flushing,
alopecia,
hypotension,
gastrointestinal distress,
constipation,
urinary difficulties.


Drug Interactions

Combivent Inhalation Aerosol has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines and steroids, commonly used in the treatment of COPD, without adverse drug reactions. No formal drug interaction studies have been performed with Combivent Inhalation Aerosol and these or other medications commonly used in the treatment of COPD.

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