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The following adverse experiences were reported in OxyContin ® -treated patients with an incidence between 1% and 5%. In descending order of frequency they were anorexia, nervousness, insomnia, fever, confusion, diarrhea, abdominal pain, dyspepsia, rash, anxiety, euphoria, dyspnea, postural hypotension, chills, twitching, gastritis, abnormal dreams, thought abnormalities, and hiccups. The following adverse reactions occurred in less than 1% of patients involved in clinical trials or were reported in postmarketing experience. General Text Continues Below
accidental injury, chest pain, facial edema, malaise, neck pain, pain, and symptoms associated with either an anaphylactic or anaphylactoid reaction Cardiovascular migraine, syncope, vasodilation, ST depression Digestive dysphagia, eructation, flatulence, gastrointestinal disorder, increased appetite, nausea and vomiting, stomatitis, ileus Hemic and Lymphatic lymphadenopathy Metabolic and Nutritional dehydration, edema, hyponatremia, peripheral edema, syndrome of inappropriate antidiuretic hormone secretion, thirst Nervous abnormal gait, agitation, amnesia, depersonalization, depression, emotional lability, hallucination, hyperkinesia, hypesthesia, hypotonia, malaise, paresthesia, seizures, speech disorder, stupor, tinnitus, tremor, vertigo, withdrawal syndrome with or without seizures Respiratory cough increased, pharyngitis, voice alteration Skin dry skin, exfoliative dermatitis, urticaria Special Senses abnormal vision, taste perversion Urogenital amenorrhea, decreased libido, dysuria, hematuria, impotence, polyuria, urinary retention, urination impaired Drug-Drug Interactions Opioid analgesics, including OxyContin ® , may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Oxycodone is metabolized in part to oxymorphone via cytochrome P450 2D6. While this pathway may be blocked by a variety of drugs (e. g., certain cardiovascular drugs including amiodarone and quinidine as well as polycyclic antidepressants), such blockade has not yet been shown to be of clinical significance with this agent. Clinicians should be aware of this possible interaction, however. Page: << Prev | 1 | 2 | 3 | Next >>
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