|
Use of OxyContin ® is associated with increased potential risks and should be used only with caution in the following conditions: acute alcoholism; adrenocortical insufficiency (e. g., Addison's disease); CNS depression or coma; delirium tremens; debilitated patients; kyphoscoliosis associated with respiratory depression; myxedema or hypothyroidism; prostatic hypertrophy or urethral stricture; severe impairment of hepatic, pulmonary or renal function; and toxic psychosis. The administration of oxycodone may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Oxycodone may aggravate convulsions in patients with convulsive disorders, and all opioids may induce or aggravate seizures in some clinical settings.
Interactions with other CNS Depressants OxyContin should be used with caution and started in a reduced dosage (1/ 3 to 1/ 2 of the usual dosage) in patients who are concurrently receiving other central nervous system
depressants including sedatives or hypnotics, general anesthetics, phenothiazines, other tranquilizers, and alcohol. Interactive effects resulting in respiratory depression, hypotension, profound sedation, or coma may result if these drugs are taken in combination with the usual doses of OxyContin. Text Continues Below
Interactions with Mixed Agonist/ Antagonist Opioid Analgesics Agonist/ antagonist analgesics (i. e., pentazocine, nalbuphine, and butorphanol) should be administered with caution to a patient who has received or is receiving a course of therapy with a pure opioid agonist analgesic such as oxycodone. In this situation, mixed agonist/ antagonist analgesics may reduce the analgesic effect of oxycodone and/ or may precipitate withdrawal symptoms in these patients. Ambulatory Surgery and Postoperative Use OxyContin is not indicated for pre-emptive analgesia (administration pre-operatively for the management of postoperative pain). Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
|
.gif)
