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By Shanida Smith, Ivanhoe Health Correspondent
CHARLOTTESVILLE, Va. (Ivanhoe Newswire) -- An international study is starting to test whether a drug commonly used for breast cancer can help relieve breast pain.
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Researchers from the University of Virginia, Columbia University in New York City, and eight other sites abroad are participating. They are studying 4-hydroxy tamoxifen in gel form that women can apply topically to treat breast pain. One quarter of participants will receive a placebo gel, one quarter will receive a half dose of 4-hydroxy tamoxifen, and one quarter will receive a full dose.
Tamoxifen (Nolvadex D, Emblon, Fentamox, Soltamox, Tamofen) is the most commonly prescribed medication for the treatment of breast cancer. The drug blocks the effects of estrogen. Researchers say estrogen and progesterone can cause breast pain in some women.
Radiologist Jennifer Harvey, M.D., from the University of Virginia, says, "It's a very common problem." Breast pain commonly occurs before the menstrual cycle and is seen frequently in post-menopausal women. Dr. Harvey says: "About one half of women will seek attention in their life for breast pain. It really disrupts life for some women."
She adds there are not effective treatments available for the condition. Researchers recommend women with breast pain avoid caffeine and take vitamin E, but Dr. Harvey says there has not been adequate data to support the efficacy of either recommendation. The drug danazol (Danocrine) has been proven effective but has major side effects.
This article was reported by Ivanhoe.com, who offers Medical Alerts by e-mail every day of the week. To subscribe, go to: http://www.ivanhoe.com/newsalert/.
SOURCE: Interview with Jennifer Harvey, M.D., April 16, 2003
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