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(Ivanhoe Newswire) -- Childhood cancer survivors face an increased risk of morbidity and mortality as a result of their curative therapies, according to a new report. Almost 75 percent of survivors will develop a chronic health condition such as diabetes, and 42.4 percent will develop a severe, disabling or life-threatening condition 30 years after diagnosis.
"In the general population, diabetes mellitus is strongly associated with an increased risk of cardiovascular disease and all-cause death," Lillian R. Meacham, M.D., of Emory University and AFLAC Cancer Center and Blood Disorders Service, Atlanta, and colleagues were quoted as saying.
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Their study compared the prevalence of diabetes in a sample of 8,599 childhood cancer survivors, diagnosed before age 21, between 1970 and 1986, and 2,936 randomly selected siblings of the survivors, average ages 31.5 and 33.4 at follow-up in 2003, respectively. Medication use, treatment exposures including irradiation, and factors that may have modified the risk of diabetes were noted.
Of the survivors, 218 reported having diabetes, while 49 siblings reported having the condition. "After adjustment for body mass index, age, sex, race/ethnicity, household income and insurance, wrote the researchers, the survivors were 1.8 times more likely than the siblings to report diabetes mellitus, with survivors who received total body irradiation, abdominal irradiation and cranial irradiation at increased risk."
"Survivors who were treated with abdominal irradiation were 2.7 times as likely to report diabetes mellitus as those who were not treated with abdominal irradiation or total body irradiation. Those treated with total body irradiation were 7.2 times as likely to report diabetes mellitus."
Survivors diagnosed with cancer before age 5 were 2.4 times more likely to report diabetes than those diagnosed in late adolescence (from ages 15 to 20). "As in the general population, older age, black or Hispanic/Latino background, lower household income, physical inactivity and increased BMI were associated with an increased risk of diabetes mellitus," the researchers noted.
"It is likely that this additional chronic disease in childhood cancer survivors, who frequently also sustain damage to the heart, kidneys and endocrine system, will lead to further morbidity and premature mortality," the authors conclude. "Therefore, it is imperative that clinicians recognize this risk, screen for diabetes and prediabetes when appropriate and approach survivors with aggressive risk-reducing strategies.
SOURCE: Archives of Internal Medicine, August 10, 2009
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